… prevent metastatic outgrowth of breast and prostate cancer cells in … Most drug development
efforts focus on shrinking existing … The hypothesis that we believe needs to be tested clinically …

… the aim of shedding light on future PRMT5 drug discovery. … (90−95) Therefore, the structure,
biological function, and … ) group on the basis of the hypothesis that the basic nitrogen of the …

… , further studies are needed to confirm this hypothesis. … palliative treatment for prostatic
carcinoma (cyproterone acetate … Similarly to other computer-aided approaches to drug discovery, …

… of their relevant biological mechanisms. This study proposed a novel method, ncRNAInter,
for LMI … group (https://idrblab.org/) has been working in the fields of AI aided drug discovery. …

… glandular cancer models such as breast or prostate cancer is … To test this hypothesis, first,
we investigated the nuclear … In this paper, we showed for the first time the molecular biology …

… of treating liver cancer and anticancer drug development. … Epigenetic changes and profiles
may be linked to the biological … resistance, including epigenetic and genetic hypotheses. In …

… accurately classified castration-resistant metastatic versus primary prostate cancers. Visualizing
the trained model generated novel hypotheses for mechanisms of metastasis in prostate …

… of prostate cancer biology and the development of new … repair defective prostate cancers,
uncovering novel roles of … A provoking hypothesis to be tested is that poor infiltration of …

… novel strategies to overcome them are an important unmet need. In this manuscript, we review
the most promising strategies to target the AR pathway in prostate cancer, … the hypothesis …

… of EED-EZH2 interaction is a novel strategy for the treatment of … Understanding the unique
biological alterations in … The success of hypothesis-driven, target-based drug discovery …